Every year, approximately 10 thousand babies are born with haemophilia worldwide and the total number of subjects with this disease is approximately 400 thousand*.

Although haemophilia has come to be regarded as a rare disease, its impact on patients’ lives is far from negligible.

With a prevalence of approximately 80% of all cases, Haemophilia A is the more common variant, in which the genetic defect causes a partial or total reduction in the activity of clotting factor VIII.


* WHO data

Given the importance of the role of Factor VIII as treatment for Haemophilia A, the Eight Factor project aims to provide a reference point for the Haemophilia Community, which consists not merely of patients, but also parents, family members and anyone else who lives in close contact with the disease.

Eight Factor aims to focus on these people and support them in their everyday lives with the disease.

This support also involves providing useful information for a better understanding of the haemophilia setting, expert statements, updates from the world of science and reports on pertinent events, as well as sharing the experiences of other patients.

Because, in the management of a disease, information and inclusion provide the strength needed to face each day with greater awareness and determination.


Learn more about the meaning of the words you read on this page and learn about the entire glossary on hemophilia.

Phase of haemostasis during which the clot forms.

It is a complex process constituted by a number of biochemical reactions that follow one another according to a specific sequence and that involve a number of proteins, including clotting factors, thrombin and fibrinogen.

A solid mass constituted by a clump of platelets held together by a mesh constituted by a protein called fibrin.

The function of the clot is to plug the opening that forms in the wall of a damaged blood vessel, in order to prevent blood loss.

Once the damage has been repaired, the clot is dissolved by specific mechanisms triggered by our body.

A group of proteins with enzymatic functions involved in the clotting process.

All clotting factors are assigned a Roman numeral, although each one also has a proper name.

Some are produced by the liver, whereas others are synthesised by the endothelial cells that make up the inner lining of the blood vessels.

Condition that occurs when factor VIII activity is between 1% and 5%.

Active involvement of the patient in the management of his/her health programme.

A protein belonging to the clotting factor category, a group of enzymes involved in the blood-clotting process.

It is encoded by a gene on the long arm of the X chromosome.

Factor VIII is also known as anti-haemophilic factor (AHF).

Condition that occurs when factor VIII activity is between 1% and 5%.

Condition that occurs when factor VIII activity is <1%.