Scientific insights
THE IMPACT OF BLEEDS AND FACTOR VIII INHIBITORS ON BONES IN CHILDREN WITH HAEMOPHILIA A
Osteoporosis, a disease characterised by low bone mineral density (BMD) and bone injury, is a matter issue of increasing concern in people with haemophilia. In recent years, many studies have been conducted on this topic, primarily in adults, but also in younger patients.1 Pathological bone metabolism is considered to be a consequence of chronic inflammation...Read all
RISK FACTORS FOR CARDIOVASCULAR DISEASE IN CHILDREN AND YOUNG ADULTS WITH HAEMOPHILIA
Cardiovascular disease is an emerging problem in the population with haemophilia. These represent a greater risk for patients with haemophilia than the general population because drugs used to treat cardiovascular disease can increase the risk of bleeding, and patients with haemophilia are also at greater risk for surgery. Hypertension, a risk factor for cardiovascular disease,...Read all
MUSCLE FUNCTION DETERIORATION IN PATIENTS WITH HAEMOPHILIA
In patients with haemophilia who have limited access to replacement therapy, including regular prophylaxis, muscle function deterioration is present beyond structural joint damage and occurs very early in life. Furthermore, despite effective prophylaxis and low bleeding rates, silent bleeds can still occur, triggering a biochemically and biomechanically vicious cycle, causing irreversible long-term joint damage. Much...Read all