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PUPs AND INHIBITORS: KNOWING THE RISK IS THE KEY TO PREVENTION

Although the development of inhibitors represents a serious danger for all patients with haemophilia A, there is a sub-population of haemophiliacs that is particularly vulnerable to this threat: PUPs (Previously Untreated Patients) suffering from severe haemophilia A, i.e. those patients with the most severe forms of factor VIII mutation and who are faced with the...
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ACQUIRED HAEMOPHILIA (AHA), THE UNEXPECTED THREAT

Haemophilia A is a genetic disease caused by the presence of mutations affecting the factor VIII gene. However, in some cases, even people who do not present any mutations can be affected by this disease. These individuals have a rare form of haemophilia A of autoimmune origin, known as Acquired Haemophilia A (AHA). In patients...
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LOW OR HIGH-TITRE INHIBITORS: WHEN CONCENTRATION MAKES THE DIFFERENCE

The appearance of factor VIII inhibitors is a problem that affects about 20-30% of patients with haemophilia and can seriously endanger their health. In order to counteract inhibitors effectively, it is of paramount importance to detect their presence as soon as possible and to determine the concentrations at which they are produced by the body....
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