The growing population of patients with haemophilia who are overweight or obese is a clinical concern.1 Recent studies have shown that 34.5% of haemophilia patients over 20 years of age in the United States are overweight and 23.5% are obese. In addition, at least 16.4% of haemophilic children are overweight compared with 13.7% of the general population.2

A study in a mouse model of haemophilia (Factor VIII-deficient F8 mice) evaluated the effect of a high-fat, high-fructose diet to understand the tendency of these animals to obesity and the risk of developing diet-induced non-alcoholic hepatic steatosis. Liver disease, whether acute or chronic, is related to coagulation disorders for a variety of reasons, including improper production of coagulation factors and inhibitors, platelet defects, hyperfibrinolysis, and increased intravascular coagulation.2

Factor VIII-deficient mice are highly prone to develop obesity as a result of a high-calorie diet and are at greater risk of developing liver disease. This weight gain and progression to fatty liver can worsen their clotting problems.2

Although further studies in patients with human haemophilia A will provide a better understanding, it is recommended that patients avoid a diet high in fat and fructose, which can lead to weight gain and hepatic steatosis.2 If this is not monitored and taken into account, replacement therapy may not be completely effective.2



  1. Andreas Tiede et al., Body Mass Index Best Predicts Recovery of Recombinant Factor VIII in Underweight to Obese Patients with Severe Haemophilia A, Thromb Haemost 2020;120:277–288, DOI https://doi.org/ 10.1055/s-0039-3400745
  2. Alaknanda Mishra, Shailendra Arindkar, Preeti Sahay, Jerald Mahesh Kumar, Pramod K. Upadhyay, Subeer S. Majumdar, and Perumal Nagarajan, Evaluation of high-fat high-fructose diet treatment in factor VIII (coagulation factor)-deficient mouse model, Int. J. Exp. Path. (2018), 99, 46–53, doi: 10.1111/iep.12264
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Learn more about the meaning of the words you read on this page and learn about the entire glossary on hemophilia.

A protein belonging to the clotting factor category, a group of enzymes involved in the blood-clotting process.

It is encoded by a gene on the long arm of the X chromosome.

Factor VIII is also known as anti-haemophilic factor (AHF).

Product containing a high concentration of freeze-dried factor VIII, used for replacement therapy in the treatment of haemophilia A.

A ereditary genetic illness, characterised by a deficiency of clotting factor VIII, that exposes the individual to a greater risk of both internal and external bleeds.

Haemophilia A is more common in males, whereas females tend to be healthy carriers of the condition.

The typical symptoms of the condition include haemarthroses (joint bleeds) and haematomas (muscle bleeds).

Condition that occurs when factor VIII activity is between 1% and 5%.

Condition that occurs when factor VIII activity is between 1% and 5%.

Condition that occurs when factor VIII activity is <1%.