Acquired haemophilia A is a rare autoimmune disease due to the formation of neutralising antibodies against coagulation factor VIII. It is characterised by a sudden onset of bleeding in patients who typically do not have a previous history of haemostasis disorders.

A German study looked at data from hospital discharge records in Germany to assess the incidence of acquired haemophilia A over the years. A total of 3289 cases of acquired haemophilia A were reported between 2010 and 2018. Comparing the first three years (2010-2012) and the last three years (2016-2018) and taking into account the growing population of Germany, an increase in the frequency of acquired haemophilia A from 2.6 to 6.0 (+ 131%) cases per million inhabitants per year was observed. Acquired haemophilia A was more often a secondary diagnosis, suggesting that the disease was not known at the time of admission or that patients were admitted primarily because of the presence of symptoms, such as bleeding, rather than because of an already known diagnosis.

Reasons to explain the increasing incidence of acquired haemophilia A in Germany include mainly better awareness and better diagnostic strategies. Access to diagnostic testing may also have played a role.

Additional efforts are needed to address the diagnostic delay that many patients with acquired haemophilia A experience and to improve their optimal management.



  • Andreas Tiede, Steffen Wahler, The rising incidence of acquired haemophilia A in Germany, Haemophilia. 2020;00:1–3. DOI: 10.1111/hae.14149
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Learn more about the meaning of the words you read on this page and learn about the entire glossary on hemophilia.

Active involvement of the patient in the management of his/her health programme.

A ereditary genetic illness, characterised by a deficiency of clotting factor VIII, that exposes the individual to a greater risk of both internal and external bleeds.

Haemophilia A is more common in males, whereas females tend to be healthy carriers of the condition.

The typical symptoms of the condition include haemarthroses (joint bleeds) and haematomas (muscle bleeds).

Condition that occurs when factor VIII activity is between 1% and 5%.

Condition that occurs when factor VIII activity is between 1% and 5%.

Condition that occurs when factor VIII activity is <1%.